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On Ice

9:19 AM  Jun 1st, 2013
by Cameron Fullam

(This article won a gold for best feature writing in the 2013 Pride of CASE V awards.)

Waiting for a transplant can put an organ recipient’s life on hold. But a tree frog that can survive freezing may hold the key to extending life by gaining time

The wipers couldn’t move any faster as they swept away the heavy snow. Julie Betz-Lugabihl ’05 peered through the windshield at the falling wall of white. Ahead of her was a large snowplow, doing its best to clear the way for the black Chevy Tahoe and its precious cargo. Behind her was a police escort, the siren lights reflecting wildly off the rearview mirror. They were the only two vehicles she had seen on Interstate 75 in hours.

Hours ago, in Dayton, someone had died. Hours later, in Toledo, Ohio, someone else would live. And the clock was ticking.

Six hours and 150 miles after leaving Dayton, Betz-Lugabihl and her colleague arrived at the University of Toledo Medical Center. The kidney in the cooler that had been secured in the backseat was still viable, and the transplant was successful. But not every organ transplant story has a happy ending.

“I’ve heard of surgeries that had to be canceled because of weather, because the organ wouldn’t be able to arrive in time,” said Betz-Lugabihl, a community relations representative with Life Connection of Ohio, a nonprofit that facilitates organ donation.

For the recipient, that means more waiting, more putting life on hold, more worrying if a match will be found in time, more staring at the phone waiting for it to ring.

“If we could extend the viability of an organ even just 24 hours, it would make a world of difference,” she said.

The key may be hiding in her backyard. The Cope’s gray tree frog — commonly found in wooded areas across the United States — survives harsh Midwestern winters by freezing. Research on the frog at the University of Dayton and Wright State University is uncovering its method of cryopreservation, a step toward developing a successful method of freezing and thawing donated organs. Understanding the tree frog could someday help transplant patients gain the time that could equal life.

In a Science Center lab in the heart of UD’s campus, professor Carissa Krane and her students are putting the tree frog’s cells under the microscope. Six years ago, they identified a protein that plays the critical role in preserving the frog’s cells and organs through freezing and thawing. The discovery was exciting, she said, because humans have the same protein, which, if activated, could hold the solution to long-term cryopreservation of organs.

carissaKrane’s research, along with others from Wright State, Ohio State and Miami universities, was featured in a story about cryopreservation of organs in the February 2013 issue of The Scientist. 

As temperatures outside drop and the days get shorter, the 2-inch frog prepares for winter. It moves less. It eats less. It hunkers down under the falling leaves. And on the inside, it
begins a process that will keep it alive as nearly 60 percent of its body water turns to ice.

Just like water anywhere, the water inside an animal freezes at 32 degrees Fahrenheit. And just like anywhere else, this freezing water expands and forms jagged ice crystals. These crystals can rip through a cell’s protective membrane and rupture its critical internal components. But even if the freezing didn’t kill the cell, the thawing would.

That’s because water seeks balance — an osmotic balance. Water will move across cell membranes to equalize concentrations of dissolved substances inside and outside of a cell.  This can sometimes result in cell swelling or shrinking, which can compromise cell function. As ice crystals thaw outside of the cell, they flood the surrounding area, forcing the water to rush into the cell, filling it quickly and bursting it like a water balloon.

Yet despite the dangers of freezing and thawing, the little tree frog survives.

Its secret is glycerol. Formed in the liver, glycerol is a type of alcohol known as a polyol. It was once used as an antifreeze in automobiles until it was replaced by polyethylene glycol.

As the frog prepares to freeze, it begins moving glycerol in and out of its cells.

The presence of glycerol inside cells helps to reduce cellular water loss that usually occurs when ice forms outside of the cell. Proteins inside the cell prevent the water inside of the cells from freezing and destroying critical components.

Outside the cell, glycerol creates a buffer between ice crystals and blunts their jagged edges, reducing their harmful effects on the cell’s outer membrane. During the thaw, glycerol flows in and out of the cell to control the rising tide of water, slowing its rush back into the cell, preventing the balloon-like burst.

Scientists have known about the cryoprotectant properties of glycerol for years, but how it moved in and out of the frog’s cells was a mystery. That changed in 2007 when Sarah Zimmerman, a graduate student in Krane’s lab, published a paper identifying the presence of a unique protein inside the frog, which she dubbed HC-3. This, Krane and her colleagues believed, was the key.

For centuries, scientists assumed water moved between cells by simply leaking through the cell membrane. While this does occur, it happens slowly. In the 1990s, American scientist Peter Agre discovered a protein that enabled the swift, organized flow of water in and out of cells. He named his discovery — for which he won the Nobel Prize in Chemistry in 2003 — aquaporins, which literally means “water channels.”

Aquaporins exist in all animals, including humans, where they assist in the formation of urine, tears and sweat. Further research has shown that some aquaporins also facilitate the movement of small solutes, including glycerol.

Aquaporins that also facilitate glycerol movement across cell membranes are known as aquaglyceroporins. This is what Zimmerman found in the frog and named HC-3. Humans have a nearly identical aquaglyceroporin called AQP-3, and it’s found in the same tissues in humans as in the frog.

But it wasn’t enough just to prove the frog had this water-glycerol channel. Krane needed to show the channel was necessary for cryoprotection. The first step was to observe the frogs

David Goldstein, a biology professor at Wright State University, visits local swamps each spring and collects about 40 frogs to bring back to his lab. There, he simulates the changing seasons, adjusting temperature, hours of sunlight and the abundance of food. He’s looking for the triggers in the environment that start the frog’s freeze process, also known as cold acclimation.

That’s when Krane comes in. She collects blood samples from both cold-acclimated and warm-acclimated frogs. She wants to know what’s happening on the inside, at the cellular level. If there is a solution to organ preservation to be found in the tree frog, she said, the cellular level is the most likely place to find it.

“The natural process that prepares the frogs for freezing takes weeks to months and is dependent upon the seasonal changes that the animals experience in the fall,” she said. “We don’t know how the animal translates the environmental cues it receives to a metabolic response that prepares them for freezing.”

She said the goal is not to induce the frog’s lengthy freezing process in humans but to understand it and determine if it can be translated to mammalian cells. “Once we know what the physiological ‘signal’ is, we can potentially induce a similar response in tissues from animals that do not naturally tolerate freezing,” she said.

The first discovery Krane and her students made was that the red blood cells of cold-acclimated frogs had a greater amount of the HC-3 protein than the red blood cells of warm-acclimated ones, a good indication that HC-3 was involved.

Next, they disabled HC-3 in the blood cells and examined what happened when the cells were exposed to the fluid conditions that exist in freezing frogs. The cells swelled at a different rate and did not recover their shape as cells with HC-3 do. The results show that HC-3 did in fact affect the cell response, further evidence that aquaglyceroporins were not only involved but also necessary.

The next question was obvious: If the aquaglyceroporin that enables freeze tolerance in the frog is also present in humans, how is it activated? Elizabeth Wetzel ’13 thinks she’s found the answer: epinephrine.

Wetzel joined Krane’s lab two years ago as a junior biology major. The team had just made an important discovery. Not only was HC-3 more abundant in cold-acclimated red blood cells than warm-acclimated ones, but it was also in a different location. In warm-acclimated cells, HC-3 floated loosely in the cytoplasm. In cold-acclimated cells, it repositioned to the cell membrane, ready for duty. Something had to tell it when to move, Wetzel thought.

She made the search for that something the focus of her senior honors thesis. To set up the experiments, she placed red blood cells in a culture to keep them alive for 48 hours. She then added potential triggers to the cells and waited 60 minutes. Placing samples of these treated cells on slides, she used a fluorescent tag to identify where the HC-3 protein was located in the cell. Under the microscope, Wetzel was able to see where the HC-3 had moved and compare it to cells that had not received the potential triggers. Time and again, one trigger emerged as the most likely candidate.

“It’s not definitive yet, but it does appear that it is the epinephrine pathway,” Wetzel said. The next step is to introduce an inhibitor that blocks epinephrine during cold acclimation to see if HC-3 fails to move to the membrane. These experiments are slated for the summer, performed by another undergraduate student. If all goes well, Krane said she hopes to submit the findings for publication in the fall.

These are steps in a long process that would include moving freeze-tolerance testing from the frog’s cells to mammalian cells.

For her part, Wetzel was invited to present her research at the Ohio Physiological Conference, the National Collegiate Research Conference at Harvard and the prestigious Experimental Biology Conference in Boston.

“A lot of people see research as just being in the lab and pipetting, but I see how it really can have huge implications and make a difference in millions of people’s lives,” she said.

This difference wouldn’t just be for the physical health benefits of the transplant recipient. If organs could be preserved longer, the gift of time itself could be life-changing, Betz-Lugabihl said.

“People on the waiting list have to put their lives on hold,” she said. “They can’t go on a family vacation. They can’t ever be more than a few hours away from the hospital. And the wait becomes so long for some, I’ve known people whose health has deteriorated to the point of not being able to brush their teeth or comb their hair.”

In Ohio, only 11 hospitals in five cities are authorized transplant centers. Often, a person in need of a transplant must relocate to one of these cities to be close to the hospital when the call comes. The disruption to life affects work, school, finances, family relationships and more.

“Just being out of their comfort zone, away from friends and familiar surroundings adds to the anxiety,” Betz-Lugabihl said. “This is on top of the waiting, on top of the wondering, will a match be found in time?”

Time.

In addition to the worries about surgery and rejection, time adds another layer of anxiety. The uncertain time spent waiting for the call. The short window of time spent rushing the donated organ to the hospital and prepping the recipient for surgery.

peter

Porter Lyons, a rising sophomore international studies major from Garrettsville, Ohio, knows this fear.

On Christmas Eve 2011, after days of fighting what he believed to be just a common cold, Lyons halted halfway down the stairs with a sudden shortness of breath. His heart began racing. His father checked his pulse and found it to be twice the normal rate.

As the paramedics rushed him to the local hospital, they discovered he had an irregular heartbeat. He was flown to nearby Cleveland Clinic where, just hours before his family had expected to be exchanging presents by their Christmas tree, Lyons was given the news. He had cardiomyopathy, and he likely only had a short time to live.

The doctors could connect his heart to a battery pack to regulate its rhythm and potentially reverse the damage. His best option, he was told, was a heart transplant.

“Saying ‘yes’ to the transplant was the easy part. It had to be done,” Lyons said. “The anxiety and fear mostly came from waiting. People are afraid of what they don’t know. The biggest fear is that if my loved one doesn’t get this organ in time, I might lose them forever.”

Lyons was immediately placed at the top of the waiting list. Just 18 hours later, he heard the good news: They had a heart.

But as quickly as the hope came, it left. The transplant surgeon determined the heart was not a good match. The waiting would continue.

Surrounded by his family and girlfriend at the time, Lyons passed the time mostly by sleeping. Occasionally he’d wake long enough to ask for an update, consume a quick snack and let the medication lull him back to sleep.

For his parents, the waiting was sadly familiar. In September of 1987, Porter’s father, Doug, found himself in the same hospital as his son, lying in a bed, unable to leave until doctors found him a new heart. In 1986, at the age of 22, Doug Lyons had been diagnosed with cardiomyopathy, an inflammation of his heart that caused it to beat irregularly. For 31 days he waited as a bedside pump moved his blood throughout his body. On Nov. 12, 1987, he received a new heart.

Almost 10 years later, on Valentine’s Day 1997, Doug Lyons was back in the Cleveland Clinic. This time he was receiving a kidney transplant, one donated by a family friend, after spending eight months on dialysis.

In both cases, the life-saving organ came in time. Would his son’s story have the same outcome?

Awaking from another nap, Porter Lyons discovered his girlfriend by his side. Just 36 hours had passed since his name was placed on the transplant waiting list, but he had lost all track of time.

“I just remember being thirsty,” he said. “So I asked for an orange juice.”

His girlfriend left the room to find a nurse and fulfill his request. But as the minutes ticked by, she did not return.

“My dad walked in a few minutes later and asked, ‘So you want some orange juice, buddy?’ By this time I was getting a little grumpy, so I replied, a bit irritated, ‘Yeah, I’m thirsty.’”

The orange juice never came. His family was stalling for time because they wanted to wait for confirmation, but in the hallway the nurse was telling them Porter couldn’t have any fluids. They had found another heart.

Not far away, a young father had died. Quickly and unexpectedly, a common sinus infection had spread to his brain. Still grieving, his family made the choice to donate his organs — his final gift, given the day after Christmas.

Only 36 hours. A day and a half after being told he would need a new heart, Porter Lyons was on the operating table.

“It was hard to accept at first,” he said. “It all happens so fast. In some ways, it seems like such a brutal process, taking these organs so shortly after someone dies, moving them around the country to put them in someone else.

“Obviously, I’m grateful for it; it’s a life-saving process. But if we could slow it down, to allow more time for loved ones to grieve, more time for doctors to make sure it’s a match, more time for the one receiving the organ to prepare, I think it would make people more comfortable. It would seem more … procedural. More … harmonious.”

Harmony. Peace of mind. Life no longer put on hold. Can it come from a small, gray tree frog that freezes to survive the winter?

“People may wonder, ‘Why give tax dollars to some scientist in a lab to play around with molecules and cells from an animal anyone can find in the woods?’” said Krane, who is sharing a three-year, $562,000 grant from the National Science Foundation with Goldstein at Wright State. “It’s a fair question, and I use it to remind myself and my students to be accountable and to carefully relate everything we do to how it can be used to improve lives.

“I’m not a Pollyanna,” she continued. “I don’t pretend to think our experiments are so important they’re going to result tomorrow in preservation of organs. We may not end up with the discovery that revolutionizes organ transplant. But we are making incremental advances, with the idea that something we come upon in a basic experiment may help someone else advance the science further.”

How long they can last between harvest and transplant:

  •  Heart and lungs, 4-6 hours
  • Liver, pancreas and small intestine, 10-12 hours
  • Kidneys, 48-72 hours

For all organs but kidneys, as soon as they are recovered they are flushed with a preservation fluid, packaged in sterile containers and packed in ice in a cooler. Kidneys can be placed on a preservation machine that is similar to dialysis, which keeps fluids circulating.

About organ donor donation:

  • To become an organ donor in Ohio, say ‘yes’ when obtaining a driver’s license or state ID; or go to www.donatelifeohio.org. Outside of Ohio, visit www.donatelife.net and click on your state.
  • A combination of increases in genetic conditions, hypertension and diabetes has added more people to the national organ transplant list at a rate faster than donors can be found.
  • The national waiting list is 117,000 people, and more than 75 percent of them need a kidney. A new name is added every 10 minutes, 150 a day. On average, 18 people a day will die because they did not receive a transplant in time.
  • While preservation would improve viability, the real issue is a shortage of donors.

— Source: Julie Betz-Lugabihl, community representative, Life Connection of Ohio.

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From gentle leading to creative destruction … Ask A Marianist

8:06 AM  Jun 1st, 2013
by Thomas M. Columbus

Brother Bernie Ploeger, S.M. ’71, president of Chaminade University in Honolulu, answers questions on the spiritual, the mathematical and the Hawaiian.

You, especially, and so many of the Marianists I’ve known have gentle, kind and lively senses of humor. Are they a reflection of the Marianist spirit? — John Geiger, Green Valley, Ariz.

Growing up in the middle of a family of four boys, our version of “talking trash” was only more gentle when viewed from today. This question brought back one of my earliest experiences of teaching. I had made a teasing remark about how dumb a student’s answer was. Then I realized I had shamed him and he could no longer pay attention to the math. Luckily, it was in an individual conversation and not in front of the whole class. Whatever I might have done with my brothers is a big failure in the classroom. An attentive teacher learns this quickly.

I suggest this is a source of this shared trait. Having said that, while I love Garrison Keillor, my candidate for the master of gentle humor, I really enjoy The Daily Show.

What is Marianist about your leadership style? — Mary Harvan Gorgette ’91, L’Hay-les-Roses, France

I’m cautious about believing if I know one’s parents or siblings, I know this person. Yet, when “everyone” says I look like my brothers — it’s true. So, that’s how I’ve come to think of shared characteristics of Marianists. Some talk of being a child of Mary. I try to be a disciple in the way Mary was. I find Mary at Cana and Mary in the upper room at Pentecost to be particularly important. I would like to believe that my leadership builds community — it is inclusive, consultative and empowering.

Do you think the Marianists are perceived any differently in Hawaii than in Dayton? —Suzette Pico, Centerville, Ohio

Although I believe there are many more things that are the same, I offer the following three as different. Because we came as missionaries (1883) and the director of the community and other brothers were personal friends of the king, leading them to oppose the overthrow of the monarch and annexation, there is an identification with the aspirations of Hawaiians that is noticeable. Related to this, from the beginning, many of the students at the schools we directed were from non-Christian families, which has led to a certain naturalness of diversity and interreligious dialogue. Finally, our small size and relative isolation (of course, this has attenuated considerably with jet travel) has meant we work more closely with other religious communities and the diocese than was my experience in Dayton.

How has the combining of the four former provinces into the Marianist Province of the U.S. had an impact on Marianist presence and mission?  — Peter Vlahutin ’94, Saint Ann, Mo.

Although numerically we have continued to decline, the formation of the new province in a very helpful way “shook things up.” When you have to explain to someone else why you’ve always done something this way — the experience of each of the four provinces — your presuppositions are challenged. So, there has been a certain “creative destruction” that I believe has been freeing. For Chaminade the mobility of personnel had led to a significant renewal and expansion in Marianist presence.

For all our institutional commitments, the unification has given even greater focus to our role as sponsors and the formation of collaborators. While we have had to consolidate the number of our communities, at the same time new initiatives have been made, most recently in Philadelphia and Los Angeles.

Has your undergrad experience in math at UD impacted your life?  — Jan Tonnis Trick ’71, Dayton

I believe what I learned that has been most central is what constitutes a theorem and its proof. Harry Mushenheim’s senior year advanced calculus courses were the time where I felt I came to understand mathematics as reasoning from axioms — always asking whether every condition of a theorem is needed, how to look for counter-examples, how to identify all the logical possibilities. He gave me an aesthetic appreciation of mathematics.

What’s your favorite way to relax? Working crossword puzzles? — Kurt Ostdiek ’91, Dayton

Kurt, I know I got you hooked on crossword puzzles, but I’ve abandoned them for KenKen. What can I say? I am a mathematician.

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How to prepare for 100 job offers

7:51 AM  Jun 1st, 2013
by Audrey Starr

When MBA grad Philippe Dubost ’07 launched his search for a new career with a unique online résumé, he hoped it would
lead to new opportunities. What he didn’t expect were the resulting job offers: all 100 of them.

“After two years with the startup company I cofounded, I decided to look for a new venture — but the idea of applying for jobs was killing me,” said the Paris-based Web entrepreneur. “I wanted to make something different.”

A mirror image of an Amazon.com product page, Dubost crafted the résumé in just two days and included it as a link with other application materials. On a whim, he shared it with a popular French blog; within five days, the résumé had gone viral, thanks to a post on social media news site Mashable.com.

One person unsurprised by his approach is Janice Glynn, director of the University’s MBA program. An exchange student from France’s Toulouse Business School, Dubost after graduation worked with Procter & Gamble Canada through a Cincinnati contracting company, then moved to San Diego for a software development job. It’s rare for international students to be hired by U.S. companies, Glynn explained, due to visa restrictions.

“He made an impression as soon as he arrived on campus as a very talented and charismatic individual,” she said.

Jason Eckert, director of UD’s career services, agreed. “From a professional standpoint, Philippe did so many ‘right’ things during his search. He’s a communicator, and this profile makes it easy for employers to find him, learn more and then reach out,” he said. “It’s also a quick, fun read. Job seekers need to acknowledge that employers don’t spend much time reviewing documents, so using clear headings and short bullet points is perfect.”

1. Imitation is more than flattery — it can get results. “Everyone loves shopping at Amazon.com and is familiar with the site and its layout,” Eckert said, noting that building on that understanding showcased Dubost’s creative potential. “It drew a lot of positive attention to his skills and background.”

2. You’re gonna need more server space. A sudden influx of visitors, from about 500 a day to more than 200,000, tested the limits of Dubost’s server capacity. He also had to upgrade his online form-builder account after the number of “contact me” submissions exceeded the cap for free service.

3. Empty your calendar. Dubost  found himself responding to more than 1,000 emails from fans, reporters and, most important, interested companies. “I’ve done my best to satisfy them all — it’s fun,” he said.

4. Expect the reunion requests. Social media helped propel Dubost’s profile from an interesting experiment to a lauded self-promotional campaign, and his former acquaintances took notice. Glynn noted that Dubost is adept at using online networking to stay in touch, periodically sending emails to the MBA program or posting updates on LinkedIn. “If he came back to campus to speak to current students, I wouldn’t have to suggest a topic; I know he’d want to talk about putting your passion into practice,” she said.

5. Polish your decision-making skills. Ultimately, Dubost’s pitch served its purpose, garnering him the job offer he’d been waiting for. He joined Birchbox, a discovery commerce platform with offices in the U.S. and Europe, at its Paris location this summer. “They’re a fantastic company with super smart people, an awesome culture, tremendous growth, and I couldn’t be happier about joining them.” Dubost is considering writing an e-book chronicling his short, but successful, hunt.

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Precious memories

2:56 PM  Feb 21st, 2013
by Meredith Hirt ’13

Jyoti Singhvi is a storyteller, but she doesn’t use paper and pen; she uses metal and jewels.

“There’s no better way to celebrate yourself for generations to come. … It’s bespoken for you and it is one-of-a-kind that tells your personal story,” Singhvi said about commissioning a custom piece from her jewelry brand, JYOTI New York.

Born in Delhi, India, and seeing her father start businesses, Singhvi was interested in entrepreneurship. Jewelry, too, was a part of her life; her ancestors established a jewelry business for India’s nobility 150 years ago. “It must be in my blood,” said Singhvi, who started designing jewelry as an adolescent.

Singhvi majored in computer science at UD two years after her family moved to Dayton, when she was 16. Before launching JYOTI New York in 2011, Singhvi worked in the e-commerce industry, earned her MBA from MIT and worked at Cartier. Singhvi also received her master’s in public administration from Harvard to help address the issues of poverty in developing countries, health care and women’s issues.

Jewelry is usually purchased to celebrate a special occasion. Singhvi desired to redesign her own ring, but most jewelry brands do not design jewelry to encompass people’s personal stories. “I design custom pieces about celebrating who you are and bringing your story to life,” Singhvi said. She sits down with each customer and learns about everything — passions, dreams, fears, important people, important occasions — and then narrates their story through jewelry. For one couple who enjoyed the adrenaline rush of bungee jumping and skydiving, Singhvi designed a ring with an innovative “Falling Rock” setting; the diamond appeared to be suspended in air. Singhvi is also launching ready-to-wear jewelry collections.

“When the final piece comes through, the client sees their story in it, and they’ve never seen anything like it before,” Singhvi said. “It is exhilarating to see their happiness and excitement.”

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My Old House 2006: 225 Kiefaber

1:42 PM  Feb 13th, 2013
by Mickey Shuey '14

The current Phi Sigma Kappa fraternity house was once a piecemeal residence for employees of NCR Corp., but for Mike Ponticelli ’06, life at 225 Kiefaber St. was full of interesting stories — including one about an iguana and its tail.

While Ponticelli didn’t become a resident of the once-pink-colored house until his junior year, his stories of “the shrimp” began as a sophomore.

“We went down to the basement at the start of the first semester to prepare it for the year,” says Ponticelli, a theater major. “We found this old coal shoot; next to it we found a really, really old pile of coal.”

Beneath that dark, dusty pile, he says, were several bottles. One was a vintage Coca-Cola bottle, but most of the others seemed to be from a traveling salesman.

“One was a snake oil canister … it was something you’d probably see at a 19th-century trade show,” he says.

The four-bedroom, two-bathroom house was one of the nicest on the block, he says.

“There was just so much space,” he recalls. “The house itself was really clean.”

The five male housemates kept things in order and didn’t have many problems.

“One exception was when one of my housemates got a pet iguana,” he recalls. “He told us, ‘Don’t touch it … if it gets scared, its tail will fall off.’ One day, my housemate saw that his could-be best-in-show iguana’s tail was off.”

The housemate blamed him for a week, Ponticelli says.

“I never touched the reptile,” he adds. “Eventually he found out that another housemate’s stereo was what caused the tail to fall off.”

As much as the housemate wanted an award-winning pet iguana, the incident shattered those dreams.

“We all laugh about it now,” says Ponticelli, now a freight broker in Boston. “It’s just one of those things that I loved about that house.

“Whether you were saying hello or staying for a few hours, people were always welcome at the Phi Sigma Kappa house.”

And take a tour of this old house with today’s residents.

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Santa’s Magic

1:32 PM  Feb 13th, 2013
by Audrey Starr

A book by Don Quigley ’63

For nearly 40 years, each December Don Quigley ’63 has done the same thing: he’s donned a familiar red suit, added a temporary white beard and spent time listening to hundreds of children detail their Christmas wishes.

“My writers’ group was really interested in my motivation — why do I keep doing this, year after year, with nothing material in return? I credit my humble childhood Christmases and the values system taught by my parents: what’s important, and what isn’t. I wanted to use the role of a mythical character to bring out that focus.”

Published in 2012, Santa’s Magic chronicles Quigley’s four-decade stint as the jolly man. He based the book on his short story about a young girl whose father was paralyzed in a car accident the month before Christmas. Her one request of Santa? To have her father walk again.

“You never know the impact you can have on someone else’s life. I later learned that until that night when she sat on Santa’s lap, she hadn’t spoken a single word since her father’s accident. After I left, she finally spent time with her father,” said Quigley, who has kept in touch with the girl and her family. He sent her a copy of the book.

Quigley is an adjunct professor in the School of Business Administration.

Read more about Quigley and his student illustrator, Katie Kandrach ’10.

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Santa tales

1:31 PM  Feb 13th, 2013
by Audrey Starr

Forget the sleigh and reindeer — sometimes, Santa Claus needs to travel in an ’84 Chevy Caprice.

That was the original transportation of choice for Don Quigley ’63, a busy sales professional by day who, for the past 30 years, has transformed into the iconic Christmas character at night. What does it take to don the familiar costume?

“Someone who gets more joy from giving to others than from receiving,” Quigley said. “It also doesn’t hurt to love to dress in a warm, plush red velvet suit and instantly look like you’ve gained 50 pounds.”

In the beginning, Quigley snuck off to his basement, perfecting a hearty “ho ho ho” and belly laugh. “My wife worried I was having a midlife crisis,” he chuckled. He recounted this and other tales in his 2012 memoir, Santa’s Magic, which also features illustrations by Katie Kandrach ’10. The two joined forces after meeting as teacher and student while Quigley was a UD business professor, a later-in-life profession that Santa gets the credit for inspiring.

“My role as Santa gave me self-confidence and self-esteem that wouldn’t have been part of my personality otherwise,” Quigley explained. After two years of portraying the mythical man, he made a career move from a computer giant to an electronics manufacturer, returning to his alma mater in 1998 as an adjunct professor. “I started by listening to children as they told me their dreams, and now they are listening to me as I teach how to pursue them.”

After three decades of use, Quigley finally traded his original Santa uniform for an updated version, which he wore again this Christmas. “Santa, the legend, can never retire,” he pointed out.

Read more about Kandrach, whose current job keeps her in the holiday spirit; and, find out how long it took Quigley to compress nearly 40 years of memories into Santa’s Magic.

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The Grimm Legacy

4:25 PM  Feb 11th, 2013
by Audrey Starr

A book by Addie J. King ’01

King modeled the main character in her first novel after her experience as a first-year law student — then, she added a talking frog. “When I learned that the Brothers Grimm had studied law before they started their folklore and linguistic studies, I was hooked,” she said. The book combines real-life scenarios (like the new student who forgets to check for first-day assignments) with a creative reimagining of Grimm fairy tales. An attorney by day, King said creative writing helps hone her legal writing skills — in turn, her legal work makes great inspiration for future fiction.

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Onward to the Dawn: A History of Tiffin University

4:09 PM  Feb 11th, 2013
by Audrey Starr

A book by Michael Anthony Grandillo ’86

Although this dissertation-turned-historiography features Tiffin’s evolution, much of the book speaks to more universal themes. “The history of higher education in Ohio embodies the American experience: of immigration, the quest for economic freedom, the escape from religious persecution, and most importantly, to our spirit of celebrating the value of education,” explained Grandillo, who serves as vice president for development and public affairs at the school. Mentions of UD, the Marianists and the city of Dayton can be found throughout.

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Rochester

3:59 PM  Feb 11th, 2013
by Audrey Starr

Run into a UD graduate in the Rochester chapter, and you’ll likely get an earful.

If you ask some of the 767 alumni in the Rochester, N.Y., chapter to talk about their alma mater, you’d better have a comfortable chair handy.

“We love to talk about UD — it’s kind of an obsession,” said chapter president Katie McGuire ’07. “Three of our alumni chapter presidents are Rochester natives. If I wear a Flyers T-shirt to the Rochester Public Market, I’m inevitably going to be stopped by someone who wants to tell me when they graduated and what house they lived in on Kiefaber.”

Proud and passionate, Rochesterians were born to be loyal Flyers, McGuire said. The chapter is known for strong event attendance, whether they have to slog through a snowstorm to make a game watch or tolerate an eight-hour bus ride back to campus for Reunion Weekend.

“We’re hearty,” McGuire explained. It doesn’t hurt that the bus trips, started years ago by longtime chapter president Frank Geraci ’73, have now reached legendary status. “We fill a bus with 50 people, everyone brings snacks and movies, and we sit together as a big cheering section at a basketball game. It’s a blast.”

They also understand how to maximize their city’s offerings. Last fall, the chapter was recognized by the Alumni Leadership Council with a Program of the Year award for its 9/11 commemoration event. The group toured the traveling exhibition “September 11, 2001: A Global Moment” and invited University political science professor Mark Ensalaco, director of human rights research, to lead a post-tour discussion.

Rochester alumni have also partnered with local agencies like the Notre Dame Learning Center, a Catholic-based tutoring program; participated in charity fundraisers like the Tour de Cure for the American Diabetes Association; and volunteered at major events like the LPGA Championship.

You can also find them getting back to their roots. They host an active Christmas off Campus event each year and organized a bowling night to connect with current UD students home on winter break. A meet-and-greet luncheon for area law grads is also in the works, McGuire said.

“There are several colleges and universities in the Rochester area, but our UD alumni chapter is larger and more active than some of theirs,” she noted. “Just ask us — we’ll be happy to tell you all about it.”

What’s your favorite Rochester festival?

“The Park Avenue Festival is one of my favorite summer festivals in Rochester; it’s always held the first full weekend of August. I have attended since I was a child and still love going.”
—Jackie Sudore-Flood ’95

“The Lilac Festival. It’s the first festival of the season, with 10 days of entertainment and yummy food.”
—Anne Marie Jankowski ’94

Fairport Canal Days!”
—Dom Zambelli ’16

Positively Pittsford, for the food and live music.”
—Trish Gramkee Kazacos ’92

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